Clearly genetic yes I will agree with that but that is only part. This is research of my disease from leading researchers.
A maternally inherited mitochondrial DNA (mtDNA) mutation is necessary but not sufficient to develop optic neuropathy. There are three common mtDNA mutations affecting complex I (i.e. m.11778G>A/MT-ND4, m.3460G>A/MT-ND1 and m.14484T>C/MT-ND6). Most cases remain as asymptomatic carriers, with males much more likely than females to undergo conversion to the affected state. Thus, male prevalence and incomplete penetrance remain areas of active investigation.
Environmental factors have now been demonstrated as frequent triggers of the disease. The most common is tobacco smoke, in combination with or without alcohol consumption (Sadun et al., 2003), as corroborated by Kirkman and colleagues (2009) with their large survey of LHON affected and unaffected mutation carriers. More rarely, exposure to toxins, various forms of smoke, or certain drugs appear to trigger the disease (Mackey et al., 2003; Luca et al., 2004; Sanchez et al., 2006; Carelli et al., 2007; Seo et al., 2010).
The VA service connected me saying it was directly service connected. I have an uphill battle and I don’t think I have a chance in hell especially the way the board thinks and how they side with the advisory opinion. I just got to throw every piece of evidence to have them rethink they should have looked at aggravation.